Proliferation Assay:Article Title: Spirocyclic compounds useful as modulators of nuclear hormone receptor function
Article Snippet: 24 hours later, the Steady-GloTM Luciferase Assay System is used to detect activity according to the manufacturer's instructions (Promega, Cat. No.: E2520). .. Murine Breast Cell Proliferation Assay: The ability of the spirocyclic compounds of the present invention (“test compounds”) to modulate the function of the AR is determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Res., 25, 1168-1175 (1965).
Article Title: Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of the compounds of the present invention to modulate the function of the AR can be determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Res., 25, 1168-1175 (1965).
Article Title: Tricycloundecane compounds useful as modulators of nuclear hormone receptor function
Article Snippet: 24 hours later, the Steady-GloTM Luciferase Assay System is used to detect activity according to the manufacturer's instructions (Promega, Cat. No.: E2520). .. Murine Breast Cell Proliferation Assay: The ability of the tricycloundecane compounds of the present invention (“test compounds”) to modulate the function of the AR is determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al, Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et.
Article Title: Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
Article Snippet: .. Proliferation Assays Murine Breast Cell Proliferation Assay The ability of compounds of the present invention (“test compounds”) to modulate the function of the AR was determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line were established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Research 25, 1168-1175 (1965).
Article Title: Bicyclic compounds as modulators of androgen receptor function and method
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of compounds of the present invention (“test compounds”) to modulate the function of the AR was determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line were established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Research 25, 1168-1175 (1965).
Article Title: Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of the compounds of Formula (I) to modulate the function of the AR can be determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo et al., Cancer Res., 25, 1168-1175 (1965).
Derivative Assay:Article Title: Spirocyclic compounds useful as modulators of nuclear hormone receptor function
Article Snippet: 24 hours later, the Steady-GloTM Luciferase Assay System is used to detect activity according to the manufacturer's instructions (Promega, Cat. No.: E2520). .. Murine Breast Cell Proliferation Assay: The ability of the spirocyclic compounds of the present invention (“test compounds”) to modulate the function of the AR is determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Res., 25, 1168-1175 (1965).
Article Title: Hexahydroimidazopyrazin-3-one compounds useful as modulators of androgen receptor function
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of the compounds of the present invention to modulate the function of the AR can be determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Res., 25, 1168-1175 (1965).
Article Title: Tricycloundecane compounds useful as modulators of nuclear hormone receptor function
Article Snippet: 24 hours later, the Steady-GloTM Luciferase Assay System is used to detect activity according to the manufacturer's instructions (Promega, Cat. No.: E2520). .. Murine Breast Cell Proliferation Assay: The ability of the tricycloundecane compounds of the present invention (“test compounds”) to modulate the function of the AR is determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al, Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo, et.
Article Title: Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function
Article Snippet: .. Proliferation Assays Murine Breast Cell Proliferation Assay The ability of compounds of the present invention (“test compounds”) to modulate the function of the AR was determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line were established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Research 25, 1168-1175 (1965).
Article Title: Bicyclic compounds as modulators of androgen receptor function and method
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of compounds of the present invention (“test compounds”) to modulate the function of the AR was determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line were established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Research 25, 1168-1175 (1965).
Article Title: Alkylene bridged sultam compounds useful as modulators of nuclear hormone receptor function
Article Snippet: .. Murine Breast Cell Proliferation Assay The ability of the compounds of Formula (I) to modulate the function of the AR can be determined by testing said compounds in a proliferation assay using the androgen responsive murine breast cell line derived from the Shionogi tumor, Hiraoka et al., Cancer Res., 47, 6560-6564 (1987). .. Stable AR dependent clones of the parental Shionogi line are established by passing tumor fragments under the general procedures originally described in Tetuo et al., Cancer Res., 25, 1168-1175 (1965).
other:Article Title: Bicyclic modulators of androgen receptor function
Article Snippet: Stable AR dependent clones of the parental Shionogi line were established by passing tumor fragments under the general procedures originally described in Tetuo, et. al., Cancer Research 25, 1168-1175 (1965).
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